A selection of peer-reviewed studies from medical and dental journals
Effects of Hypochlorous Acid Solutions on Venous Leg Ulcers (VLU): Experience With 1249 VLUs in 897 Patients. Bongiovanni CM., J Am Coll Clin Wound Spec. 2016 Jan 21;6(3):32-7.
Antimicrobial efficacy, mode of action and in vivo use of hypochlorous acid (HOCl) for prevention or therapeutic support of infections. Boecker D, Zhang Z, Breves R, Herth F, Kramer A, Bulitta C. GMS Hyg Infect Control. 2023 Mar27;18:Doc07.
Hypochlorous Acid: An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm, and Wound Healing Potency. Sakarya, S., et al. (2014).Wounds, 26(12), 342-350.
Hypochlorous Acid as a Potential Wound Care Agent: Part I. Stabilized Hypochlorous Acid: A Component of the Inorganic Armamentarium of Innate Immunity. Wang, L., et al. (2007). Journal of Burns and Wounds, 6, e5.
Hypochlorous Acid as a Potential Wound Care Agent: Part II. Stabilized Hypochlorous Acid: Its Role in Decreasing Tissue Bacterial Bioburden and Overcoming the Inhibition of Infection on Wound Healing. Robson, M. C., et al. (2007). Journal of Burns and Wounds, 6, e6.
The effects of pH on wound healing, biofilms, and antimicrobial efficacy. Percival, S. L., et al. (2014). Wound Repair and Regeneration, 22(2), 174-186.
Evaluation of the Antibacterial Efficacy and Biocompatibility of a Hypochlorous Acid-Based Solution for Wound Healing. Luca, J., et al. (2020). International Journal of Lower Extremity Wounds, 19(4), 415-421.
Hypochlorous Acid: Applications in Dermatology. Natarelli N, Nong Y, Maloh J, Sivamani R. (2022). Journal of Integrative Dermatology.
The Lesson Learned from the COVID-19 Pandemic: Can an Active Chemical Be Effective, Safe, Harmless-for-Humans and Low-Cost at a Time? Evidence on Aerosolized Hypochlorous Acid. Benedusi M, Tamburini E, Sicurella M, et al. , Int J Environ Res Public Health. 2022 Oct 13;19(20):13163.
Hypochlorous Acid: A Review. Block MS, Rowan BG. J Oral Maxillofac Surg. 2020 Sep;78(9):1461-1466.
Electrolyzed water (HOCl) for the microbiologic control in the pandemic dental setting: a systematic review. Cárdenas AM, Campos-Bijit V, Di Francesco F, Schwarz F, Cafferata EA, Vernal R.,BMC Oral Health. 2022 Dec.
​
Effects of stabilized hypochlorous acid on oral biofilm bacteria. Aherne O, Ortiz R, Fazli MM, Davies JR. BMC Oral Health. 2022 Sep 20;22
​
Centers for Disease Control: Guideline for Disinfection and Sterilization in Healthcare Facilities, Rutala WA, Weber DJ, et al, 2008, Update: May 2019
​
Hypochlorous acid as a disinfectant for high-risk HPV: Insight into the mechanism of action. Robins LI, Clark A, Gafken PR, Alam S, Milici J, Hassan R, Wang CY, Williams J, Meyers C. J Med Virol. 2022 Jul;94(7)
Efficacy of hypochlorous acid as an alternative oral antimicrobial agent on human gingival fibroblasts, aggregatibacter actinomycetemcomitans, and candida albicans biofilms in vitro, Bayraktar G, Göler AM, Aksu B, Özene HO, The Journal of Bioadhesion and Biofilm Research June 2023
HOCl Rapidly Kills Corona, Flu, and Herpes to Prevent Aerosol Spread. Guan H, Nuth M, et al,
J Dent Res. 2023 Aug;102(9):1031-1037.
Evaluation of liquid- and fog-based application of Sterilox hypochlorous acid solution for surface inactivation of human norovirus. Park GW, Boston DM, Kase JA, Sampson MN, Sobsey MD., Appl Environ Microbiol. 2007 Jul;73(14):4463-8.
Electrolyzed water for the microbiologic control in the pandemic dental setting: a systematic review. Cárdenas AM, et al, BMC Oral Health. 2022 Dec 9;22(1):579.
Dental unit waterline disinfection using hypochlorous acid-based disinfectant, Shajahan IF, et al, J Conserv Dent. 2016 Jul-Aug; 19(4): 347–350.
Antimicrobial Efficiency of Hypochlorous Acid and Its Effect on Some Properties of Alginate Impression Material, Bayan S.Khalaf , ShorouqM. Abass, International Journal of Dentistry, Vol 2023
Substantivity of hypochlorous acid-based disinfectant against biofilm formation in dental unit waterlines. Shajahan IF, Kandaswamy D, et al. J Conserv Dent. 2017 Jan-Feb;20(1):2-5.
Hypochlorous Acid: Harnessing an Innate Response, Williams J, Rasmussen E, Robins L, InfectionControl.tips, 2017
Electrolyzed Hypochlorous Acid (HOCl) Aqueous Solution as Low-Impact and Eco-Friendly Agent for Floor Cleaning and Sanitation. Gessi A, Formaglio P, Semeraro B, Summa D, Tamisari E, Tamburini E. Int J Environ Res Public Health. 2023 Sep 5;20(18):6712.
Efficacy of hypochlorous acid (HOCl) fog in sanitizing surfaces against Enterococcus faecalis., Feng KC, Ghai A, Liu H, Salerno A, Miller C, Liu J, Manesh S, Cymerman J, Simon M, Walker SG, Rafailovich M. Am J Infect Control. 2022 Dec;50(12):1311-1315.